Ph.D. Programme in Biomedical Sciences is a programme of the Doctoral School of Exact and Natural Sciences with a strong interdisciplinary, international, inter-sectoral research and training dimension.

The programme covers various areas of biology (synthetic, structural, molecular, cellular, developmental) and medicine (studies on endothelium) and utilises plants, viruses, bacteria, invertebrates, and vertebrates.

Training will be focused on the interests and expertise of researchers working at the Malopolska Centre of Biotechnology (MCB), Jagiellonian Centre for Experimental Therapeutics (JCET) and National Synchrotron Radiation Centre (SOLARIS).

Successful applicants will then work in at least one of the three excellent and interdisciplinary institutes  – MCB, JCET or SOLARIS. The institutes are staffed by international world-class scientists and are publishing research at the highest level. 

Students offered a place in our funded Ph.D. programme will obtain full financial support regardless of nationality. Since our studentships are extremely competitive, we also encourage you to seek your own funding.

The programme is run in English, either in an eight-semester or in six-semester system.

During their Ph.D., students are expected to attend training courses in transferable and general research skills, participate in the students' and outreach activities, present their work regularly and attend seminar. More information about the programme can be found here.

Szczegółowe warunki i tryb rekrutacji

Wymagane dokumenty [w j. angielskim]

Recruitment schedule:

• Opening of the competition: 09.11.2021
• Application submission deadline: 28.11.2021
• Entrance exams: 08-09.12.2021
• Announcement of results: 10.12.2021
• Enrollment: 20-21.12.2021
• Enrollment: (reserve list): 22.12.2021

Please send your applications to: magdalena.pisarczyk@uj.edu.pl and biomedical.phd@uj.edu.pl

To make the application process fast and easy, please follow the rules. Remember to send your application to: biomedical.phd@uj.edu.pl and magdalena.pisarczyk@uj.edu.pl

Project description:

The stability of the 3D structure of proteins under extreme conditions (high pressures, high temperatures, extreme pH or ionic strength values, etc.) is still one of the current problems in fundamental research. The stability of the structure of protein complexes, oligomeric or monomeric proteins at high pressures is also of great importance in their industrial use. On the other hand, understanding the processes related to local structural disorder (e.g. changes in secondary structure) as well as long-range changes (dissociation of oligomeric structures or even complete unfolding of the tertiary structure) induced by pressure is important for understanding these phenomena in a broader (fundamental) context. It is particularly interesting to link these changes, induced by high pressure, with ranges of enzymatic activity or mechanisms of the misfolding of protein structures associated with neurodegenerative diseases (eg. human cystatin C or human prion protein). The aim of this project is to investigate the influence of high pressure (even up to 2 GPa) on the spatial structure of model proteins.