Przejdź do głównej treści
Wersja kontrastowa
en English Menu
"

Widok zawartości stron Widok zawartości stron

Pomiń baner

Rekrutacje grantowe

Konwersatoria

Konkursy ID.UJ

Dla Doktorantów

Nawigacja okruszkowa Nawigacja okruszkowa

Widok zawartości stron Widok zawartości stron

Head of the PhD study programme:

dr hab. Piotr Rozpądek, Prof. UJ
phone: +48 12 664 6108
e-mail: piotr.rozpadek@uj.edu.pl

PhD Student Administration Office:

mgr Magdalena Pisarczyk
phone: +48 453 672 171
magdalena.pisarczyk@uj.edu.pl

 

Limits of places
[regular recruitment] 2023/24:

1st round (June/July):

MCB: 1
JCET: 2
Solaris: 2

2nd round (September):

MCB: 3
JCET: 0
Solaris: 1

3rd round (October/November):

MCB: 2
JCET: 0
Solaris: 0

Admission:

Admission rules
Admission rules [PL version]
Required documents
Required documents [PL version]
Schedule

Apply via: Online Application System

Past calls:

List of past calls

Widok zawartości stron Widok zawartości stron

>>PhD study programme in Biomedical Sciences<< v. 22/23  [eight-terms]
>>PhD study programme in Biomedical Sciences << v. 22/23 [six-terms]

List of potential PhD advisors [MCB]

PhD Programme in Biomedical Sciences is a programme at the Doctoral School of Exact and Natural Sciences the Jagiellonian University in Krakow with a strong inter-disciplinary, international inter-sectoral research and training dimension.

We will recruit early stage researchers (ESRs) in an open call, targeting the most talented and motivated ESRs in the fields of Biological and Medical Sciences. The recruitment process will adhere to the guidelines set in the code of conduct for the recruitment of researchers and the European charter for researchers, ensuring transparency of the recruitment process based on the merit and skills of applicants. The recruitment process will not discriminate applicants based on their personal features.
Training will be focused on the interest and expertise of researchers working at the Malopolska Centre of Biotechnology (MCB), Jagiellonian Centre for Experimental Therapeutics (JCET) and National Synchrotron Radiation Centre (SOLARIS).
The program covers various areas of biology:

  • synthetic,
  • structural,
  • molecular,
  • cellular,
  • developmental

and utilizes plants, viruses, bacteria, invertebrates and vertebrates.
The program is also linked to interdisciplinary studies in endothelial biomedicine. 

Our Students offered a place in our PhD programme will obtain a full scholarship funded by the Polish government regardless of nationality.
The applicants are free to choose the research topic and supervisors from the focus areas based on their personal interests and qualifications. We encourage our students to get involved in the broad range of scientific activities of MCB, JCET and Solaris research groups. It is also an excellent opportunity to learn to think across disciplines and build up initial collaborations and cross-disciplinary skill sets.
The programme is run in English, either in a six-semester or in an eight-semester system.
During their studies, our students are expected to attend training courses in transferable and general research skills, participate in the students' and outreach activities, present their work regularly and attend seminars.

Widok zawartości stron Widok zawartości stron

M3. Mechanism of action of stem cell-specific lncRNAs at molecular and cellular levels (dr hab. Przemysław Grudnik & dr Marta Pabiś)

Supervisors:

dr hab. Przemysław Grudnik
dr Marta Pabiś (project leader)

Malopolska Centre of Biotechnology (MCB)

Project description:

The project is designed to uncover the mechanism of action of selected human pluripotent stem cell (PSC)-specific lncRNAs. Although over 170 000 human lncRNAs transcripts are reported in most recent releases of databases (e.g. NONCODE), only a part of those RNAs have been attributed a biological function based on specific experimental studies reported in literature. Moreover, their interaction with binding partners (e.g. proteins) and mechanisms of action underlying their cellular functions are still far from being well understood. There is also a shortage of experimental data concerning lncRNA structure. The PhD student will apply structural biology and biochemical approaches to address these unknowns and work in close collaboration with the Postdoctoral researcher who will focus on lncRNA mechanisms of action on the cellular level. The planned scope of the PhD student work is the following:

  • Determination of two-dimensional structures and identification of structural modules of the selected lncRNAs using bioinformatic and chemical probing approaches
  • Confirmation of direct interactions with protein binding partners reported in literature and identified within our studies, as well as their biochemical characterization in vitro
  • Identification of the localization of protein binding sites on the lncRNAs, both in vitro and in cells (the later in collaboration with the Postdoctoral researcher)
  • Three-dimensional structural analysis of largest stable fragments of studied lncRNAs with and without protein-binding partners by cryo-EM and crystallography
  • Validation of structural data in cells (in collaboration with the Postdoctoral researcher)

Candidate profile:

  • MSc or equivalent degree in biology, biotechnology, chemistry or other relevant field
  • Interest in RNA biology and structural biology
  • Basic experience in molecular biology and biochemistry
  • Previous experience in structural biology techniques is not required but is a plus
  • Very good knowledge of English (written and spoken)
  • Very good presentation and communication skills
  • High motivation and engagement in research work, reasonable level of independence at work, positive attitude, good organizational skills, ability of multitasking