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Head of the PhD study programme:

dr hab. Piotr Rozpądek, Prof. UJ
phone: +48 12 664 6108
e-mail: piotr.rozpadek@uj.edu.pl

PhD Student Administration Office:

mgr Magdalena Pisarczyk
phone: +48 453 672 171
magdalena.pisarczyk@uj.edu.pl

 

Limits of places
[regular recruitment] 2023/24:

1st round (June/July):

MCB: 1
JCET: 2
Solaris: 2

2nd round (September):

MCB: 3
JCET: 0
Solaris: 1

3rd round (October/November):

MCB: 2
JCET: 0
Solaris: 0

Admission:

Admission rules
Admission rules [PL version]
Required documents

Required documents [PL version]
Schedule

Apply via: Online Application System

Past calls:

List of past calls

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>>PhD study programme in Biomedical Sciences<< v. 22/23  [eight-terms]
>>PhD study programme in Biomedical Sciences << v. 22/23 [six-terms]

List of potential PhD advisors [MCB]

PhD Programme in Biomedical Sciences is a programme at the Doctoral School of Exact and Natural Sciences the Jagiellonian University in Krakow with a strong inter-disciplinary, international inter-sectoral research and training dimension.

We will recruit early stage researchers (ESRs) in an open call, targeting the most talented and motivated ESRs in the fields of Biological and Medical Sciences. The recruitment process will adhere to the guidelines set in the code of conduct for the recruitment of researchers and the European charter for researchers, ensuring transparency of the recruitment process based on the merit and skills of applicants. The recruitment process will not discriminate applicants based on their personal features.
Training will be focused on the interest and expertise of researchers working at the Malopolska Centre of Biotechnology (MCB), Jagiellonian Centre for Experimental Therapeutics (JCET) and National Synchrotron Radiation Centre (SOLARIS).
The program covers various areas of biology:

  • synthetic,
  • structural,
  • molecular,
  • cellular,
  • developmental

and utilizes plants, viruses, bacteria, invertebrates and vertebrates.
The program is also linked to interdisciplinary studies in endothelial biomedicine. 

Our Students offered a place in our PhD programme will obtain a full scholarship funded by the Polish government regardless of nationality.
The applicants are free to choose the research topic and supervisors from the focus areas based on their personal interests and qualifications. We encourage our students to get involved in the broad range of scientific activities of MCB, JCET and Solaris research groups. It is also an excellent opportunity to learn to think across disciplines and build up initial collaborations and cross-disciplinary skill sets.
The programme is run in English, either in a six-semester or in an eight-semester system.
During their studies, our students are expected to attend training courses in transferable and general research skills, participate in the students' and outreach activities, present their work regularly and attend seminars.

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M1. Molecular mechanisms of RNA upregulation in Trisomy 21 (dr hab. Magdalena Masłoń)

Supervisor: dr hab. Magdalena Masłoń

Malopolska Centre of Biotechnology (MCB)


Project description:

Down Syndrome is a common genomic disorder of intellectual disability, caused by a supernumerary copy of chromosome 21 (trisomy 21, T21). Somatic gain of chromosome 21 is also one of the most frequent copy number variations found in several types of leukemia. Surprisingly, T21 cells not only overexpress genes carried by chromosome 21 but have a globally increased RNA content and misexpress genes on other chromosomes too. The mechanism and molecular consequences of RNA amplification in T21 cells remain unexplored, despite its medical relevance. We aim to describe these pathways. Knowledge gained in this project will be fundamental to developing successful therapies to conditions with abnormal karyotypes.

PhD candidate will use a range of genomics approaches and genetic screens in the relevant cellular models to uncover mechanisms enabling amplification of RNA Polymerase II transcription in T21 cells.

Qualifications:

  • Must hold MSc degree in Life Sciences
  • Has a laboratory experience, supported by references of the academic supervisors
  • Has a good knowledge of molecular biology and gene expression regulation
  • Has a professional command of English
  • Has a genuine interest in gene expression