Przejdź do głównej treści

Widok zawartości stron Widok zawartości stron

Pomiń baner

Widok zawartości stron Widok zawartości stron

Head of the PhD study programme:

dr hab. Piotr Rozpądek
phone: +48 12 664 6108
e-mail: piotr.rozpadek@uj.edu.pl

PhD Student Administration Office:

mgr Magdalena Pisarczyk
phone: +48 12 664 4525
magdalena.pisarczyk@uj.edu.pl

 

Limits of places
[regular recruitment]:

September round:

MCB: 2 places
JCET: 2 places
Solaris: -

July round:

MCB: 3 places
JCET: 5 places
Solaris: 2 places

Admission:

​>> Online Application System <<

Past calls:

List of past calls

Widok zawartości stron Widok zawartości stron

>>PhD study programme in Biomedical Sciences<< v. 22/23  [eight-terms]
>>PhD study programme in Biomedical Sciences << v. 22/23 [six-terms]

List of potential PhD advisors [MCB]

PhD Programme in Biomedical Sciences is a programme at the Doctoral School of Exact and Natural Sciences the Jagiellonian University in Krakow with a strong inter-disciplinary, international inter-sectoral research and training dimension.

We will recruit early stage researchers (ESRs) in an open call, targeting the most talented and motivated ESRs in the fields of Biological and Medical Sciences. The recruitment process will adhere to the guidelines set in the code of conduct for the recruitment of researchers and the European charter for researchers, ensuring transparency of the recruitment process based on the merit and skills of applicants. The recruitment process will not discriminate applicants based on their personal features.
Training will be focused on the interest and expertise of researchers working at the Malopolska Centre of Biotechnology (MCB), Jagiellonian Centre for Experimental Therapeutics (JCET) and National Synchrotron Radiation Centre (SOLARIS).
The program covers various areas of biology:

  • synthetic,
  • structural,
  • molecular,
  • cellular,
  • developmental

and utilizes plants, viruses, bacteria, invertebrates and vertebrates.
The program is also linked to interdisciplinary studies in endothelial biomedicine. 

Our Students offered a place in our PhD programme will obtain a full scholarship funded by the Polish government regardless of nationality.
The applicants are free to choose the research topic and supervisors from the focus areas based on their personal interests and qualifications. We encourage our students to get involved in the broad range of scientific activities of MCB, JCET and Solaris research groups. It is also an excellent opportunity to learn to think across disciplines and build up initial collaborations and cross-disciplinary skill sets.
The programme is run in English, either in a six-semester or in an eight-semester system.
During their studies, our students are expected to attend training courses in transferable and general research skills, participate in the students' and outreach activities, present their work regularly and attend seminars.

Widok zawartości stron Widok zawartości stron

Studies on the role of energy metabolism compartmentalization in the activity and function of blood platelets in health and disease (Supervisor: dr hab. Patrycja Kaczara)

Studies on the role of energy metabolism compartmentalization in the activity and function of blood platelets in health and disease (Supervisor: dr hab. Patrycja Kaczara)

Project description

Thrombosis, which is associated with various cardiovascular diseases, is one of the leading clinical concerns associated with high morbidity and mortality. Importantly, blood platelets in patients with metabolic diseases often exhibit hyperreactivity, leading to an increased risk of cardiovascular events related to thrombosis. Platelet aggregation is an energy-demanding process that can be supported by ATP provided by both glycolysis and mitochondrial respiration (Kaczara et al., ATVB 2020; https://doi.org/10.1161/ATVBAHA.120.314284). Under healthy conditions, glycolysis appears to predominate in ATP delivery over oxidative phosphorylation. In turn, mitochondria emerge as organelles with many important functions related not only to platelet bioenergetics, but also to the functioning of platelets and other types of cells (see, e. g., Levoux et al., Cell Metabolism 2021; https://doi.org/10.1016/j.cmet.2020.12.006). It is known that beyond ATP production, cellular metabolism controls the fate of cells. However, it is not yet clear how the balance between the cytosolic and mitochondrial energy metabolism processes affects the activity of blood platelets. 

The central hypothesis of the project is that the imbalance balance between cytoplasmic and mitochondrial energy metabolism processes induces the development of platelet hyperreactivity. The aim of the project is to investigate the role of compartmentalization of bioenergetic processes in platelet energy metabolism and function. Pharmacological modulation of metabolic pathways will be a tool for observing changes at the molecular, organellar and cellular levels by analyzing metabolic fluxes, ROS and calcium signaling, mitochondrial quality control, and platelet function.  In turn, exposure of platelets to different metabolic fuels will reveal physiological relevance of the investigated processes, especially with regard to the conditions of metabolic diseases. The results of the project are expected to identify new metabolic targets for the development of innovative antiplatelet therapies that protect against or decrease thrombosis. 

How to apply?

To make the application process fast and easy, please follow the rules. Remember to send your application to Online Application System.

Polecamy również
Extended microbiome characterization by the exploitation of the microbial intra-community synergies (Supervisor: dr hab. inż. Paweł Łabaj)
Extended microbiome characterization by the exploitation of the microbial intra-community synergies (Supervisor: dr hab. inż. Paweł Łabaj)
Regulation of uterus invasion by the blastocyst – role of embryonic exosomes (Supervisor: Prof. dr hab. Grażyna Ptak)
Regulation of uterus invasion by the blastocyst – role of embryonic exosomes (Supervisor: Prof. dr hab. Grażyna Ptak)
Searching for compensatory mechanisms in type 1 diabetes (Supervisor: dr hab. Maria Walczak)
Searching for compensatory mechanisms in type 1 diabetes (Supervisor: dr hab. Maria Walczak)