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Pomiń baner

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Head of the PhD study programme:

dr hab. Piotr Rozpądek
phone: +48 12 664 6108
e-mail: piotr.rozpadek@uj.edu.pl

PhD Student Administration Office:

mgr Magdalena Pisarczyk
phone: +48 12 664 4525
magdalena.pisarczyk@uj.edu.pl

 

Limits of places
[regular recruitment]:

September round:

MCB: 2 places
JCET: 2 places
Solaris: -

July round:

MCB: 3 places
JCET: 5 places
Solaris: 2 places

Admission:

​>> Online Application System <<

Past calls:

List of past calls

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>>PhD study programme in Biomedical Sciences<< v. 22/23  [eight-terms]
>>PhD study programme in Biomedical Sciences << v. 22/23 [six-terms]

List of potential PhD advisors [MCB]

PhD Programme in Biomedical Sciences is a programme at the Doctoral School of Exact and Natural Sciences the Jagiellonian University in Krakow with a strong inter-disciplinary, international inter-sectoral research and training dimension.

We will recruit early stage researchers (ESRs) in an open call, targeting the most talented and motivated ESRs in the fields of Biological and Medical Sciences. The recruitment process will adhere to the guidelines set in the code of conduct for the recruitment of researchers and the European charter for researchers, ensuring transparency of the recruitment process based on the merit and skills of applicants. The recruitment process will not discriminate applicants based on their personal features.
Training will be focused on the interest and expertise of researchers working at the Malopolska Centre of Biotechnology (MCB), Jagiellonian Centre for Experimental Therapeutics (JCET) and National Synchrotron Radiation Centre (SOLARIS).
The program covers various areas of biology:

  • synthetic,
  • structural,
  • molecular,
  • cellular,
  • developmental

and utilizes plants, viruses, bacteria, invertebrates and vertebrates.
The program is also linked to interdisciplinary studies in endothelial biomedicine. 

Our Students offered a place in our PhD programme will obtain a full scholarship funded by the Polish government regardless of nationality.
The applicants are free to choose the research topic and supervisors from the focus areas based on their personal interests and qualifications. We encourage our students to get involved in the broad range of scientific activities of MCB, JCET and Solaris research groups. It is also an excellent opportunity to learn to think across disciplines and build up initial collaborations and cross-disciplinary skill sets.
The programme is run in English, either in a six-semester or in an eight-semester system.
During their studies, our students are expected to attend training courses in transferable and general research skills, participate in the students' and outreach activities, present their work regularly and attend seminars.

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Systems Biology to Embrace Complexity in Heart Failure with Preserved Ejection Fraction – Novel Concepts in Altered Cardiac Energy Metabolism and Potential New Therapeutic Targets (Supervisor: dr hab. Mariola Olkowicz)

Systems Biology to Embrace Complexity in Heart Failure with Preserved Ejection Fraction – Novel Concepts in Altered Cardiac Energy Metabolism and Potential New Therapeutic Targets (Supervisor: dr hab. Mariola Olkowicz)

Project description

Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome with heterogeneous pathophysiology and presentation [1]. The limited availability of representative animal models that may recapitulate the clinical features of human HFpEF along with the corresponding complexity of the biological networks occurring in a large number of tissues and cell type under these challenging conditions constitute the major obstacles in conducting mechanistic studies elucidating the pathophysiology of this syndrome. In that context, systems biology – the study of complex interactions in biological systems and the emergent properties that arise from such interactions supported by rapid technological advances which enable highthroughput and systematic profiling of cellular genome, transcriptome, proteome, metabolome, to name a few – represents a powerful approach in HFpEF pathophysiology investigations [2].

The main goal of the research will be to identify the most relevant and integrative biological mechanisms of metabolic dysfunction in HFpEF that can be therapeutically targeted and potentially clinically transferred for the benefit of patients. In addition, this study aims to explore metabolic mechanisms of improved patient outcome in regard to new therapies including SGLT2 inhibitors or other metabolism-affecting drugs. On methodological level, this project will be based on interdisciplinary, state-of-the-art methodologies that will include, among others, modern Omics technologies (NGS transcriptomics, proteomics, metabolomics, lipidomics), modern tools in preserving the intact metabolome/lipidome (solid-phase microextraction), unique strategies to integrate multi-omics datasets (based on machine learning and artificial intelligence) as well as a wide scope of other studies, at functional, biochemical and molecular levels that all will be carried out in the unique model for hyperlipidaemia and atherosclerosis that possesses human- like lipoprotein metabolism (E3L.CETP mice). 
 
Fig. 1. The photograph of Thin-Film Solid-Phase Microextraction (TF-SPME) blades covered with a biocompatible extraction phase that will be applied for metabolites’ extraction from coronary effluents collected during isolated hearts perfusion to verify about cardiac fuel use in ex vivo setting.
[1]. Mishra S, et al. Cellular and molecular pathobiology of heart failure with preserved ejection fraction. Nat Rev Cardiol. 2021 Jun; 18(6):400-423. [2]. Gibb AA, et al. Molecular Signature of HFpEF: Systems Biology in a Cardiac-Centric Large Animal Model. JACC Basic Transl Sci. 2021 Aug 23; 6(8):650-672.

How to apply?

To make the application process fast and easy, please follow the rules. Remember to send your application to Online Application System.

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