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Kontakt:
Maksymilian Szymczak
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Metabolic reprogramming in age-dependent endothelial dysfunction and vascular stiffness; novel mechanism of inflamm-ageing (Supervisor: prof. dr hab. S. Chłopicki)
Project description:
Chronic, sterile, low-grade inflammation observed in older organism that have been recently named “inflamm-ageing”, results in accelerated development of endothelial dysfunction and large arteries stiffness and can be associated with alterations in vascular mitochondrial function [1, 2]. Systemic endothelial dysfunction and increased stiffness of large arteries, can be measured in clinical conditions, and predict morbidity and mortality of cardiovascular diseases. Accordingly, the improvement in endothelial function and artery stiffness can have therapeutic effects. However, mechanisms involved in inflamm-ageing are not clear.
We hypothesize that accelerated age-dependent dysfunctional vasculature in E3L.CETP mice with humanized dyslipidaemia and in some other unique animal models might be explained by vascular metabolic reprogramming that could contribute to vascular inflamm-ageing and subsequently to persistent vascular inflammation, to endothelial dysfunction and arterial stiffness. We aim to characterize metabolic signature of inflamm-ageing in murine models, and in particular to define the mechanisms and importance of metabolic reprogramming in the development of age-dependent endothelial dysfunction in large arteries and in coronary microcirculation, as well as in arterial stiffness. This project will be based on interdisciplinary, state-of-the art methodologies including e.g.; Magnetic Resonance Imaging – MRI to assess endothelial function in vivo in mice, vascular preparations ex vivo, as well as microfluidic device to characterize in vitro primary endothelial cells isolated from mice. Targeted and non-targeted metabolomics will be used to define metabolic pathways of dysfunctional endothelium and vascular wall. The research is carried out in the frame of MAESTRO grant and international collaboration.
[1] Liberale L, Montecucco F, Tardif JC, Libby P, & Camici GG (2020). Inflamm-ageing: the role of inflammation in age-dependent cardiovascular disease. Eur Heart J 41, 2974-2982.
[2] Tyrrell DJ, Blin MG, Song J, Wood SC, & Goldstein DR (2020). Aging Impairs Mitochondrial Function and Mitophagy and Elevates Interleukin 6 Within the Cerebral Vasculature. J Am Heart Assoc 9, e017820.
Candidate should fulfil the following criteria:
- master or equivalent degree in biological, medical, pharmaceutical or related areas,
- basic knowledge in vascular cellular metabolism, and in experimental pharmacology
- some experience in experimental laboratory work
- excellent communication skills and fluent English
- enthusiasm for scientific work
- ability to work in teams
www.jcet.eu
How to apply?
Send your application documents to biomedical.phd@uj.edu.pl and to the Project Manager - Prof. dr hab. Stefan Chłopicki e-mail: stefan.chlopicki@jcet.eu.
Schedule of the competition:
- Opening of the competition: 04.11.2022
- Application submission deadline: 08.11.2022, noon
- Entrance exams: 24.11-25.11.2022
- Committee meeting - no later than: 25.11.2022
- Exam results: 28.11.2022
- Entries to the Doctoral School: 29.11-01.12.2022
- Entries to the Doctoral School - reserve list: 02.12.2022
Detailed terms and procedures of admission.
Documents required at the recruitment application stage:
- a curriculum vitae (CV) with particular emphasis on scientific achievements;
- a motivation letter, explaining how the applicant’s background and research interests make them a suitable candidate for the position;
- the names of the researchers giving references to the candidate (their contact number and academic title);
- documents demonstrating the scientific achievements listed in the curriculum vitae, e.g. first page of the article;
- transcript of grades: diploma supplement or the official transcript of grades, or another document listing completed courses and grades. Information about the grading scale must be included.
In the event of the persons referred to in Article 186, section 2 of the Act,
- two opinions confirming the high quality of their research work and the high level of
- advancement of such work, issued by: a research fellow holding at least the academic degree
- of doctor habilitated or being an employee of a foreign higher education institution or a
- research institution, that has significant achievements in academic issues related to the
- curriculum.
Any document submitted in a language other than Polish or English must be accompanied by a certified translation into Polish or English.
Documents required for enrollment:
- the original application and a photograph;
- a photocopy and the original for inspection:
- a. a diploma certifying the holding of a degree of Master, Master Engineer or equivalent in a field of study from among those indicated in the detailed conditions of recruitment, or
- b. a diploma of completion of studies abroad, giving the right to enrol in a course of doctoral studies in the issuing country or recognised as equivalent to the appropriate Polish diploma confirming the qualifications of the second degree; if the candidate has not yet been issued such a diploma by the deadline for admission, he/she shall submit a certificate of completion of such studies and a written undertaking to provide the diploma of higher education entitling to enrol in a course of doctoral studies within the prescribed deadline;
- for inspection: identity document (passport in case of foreigners);
- originals of all other documents provided at the registration stage in the form of a scan.
In the event of exposure to harmful, noxious or hazardous factors, the applicant will, at the time of registration, be referred for a medical examination by an occupational medicine physician. The candidate shall be obliged to deliver, within the time limit set by the programme manager, a medical certificate confirming the absence of contraindications to take up education.
Higher education diplomas awarded abroad should:
- bear an apostille clause if the issuing country is covered by the Convention abolishing the requirement legalisation for foreign public documents, done at The Hague on 5 October 1961 (Journal of Laws of 2005, No. 112, item 938) or
- be subjected to legalisation, in other cases.
Any document submitted in a language other than Polish or English must be accompanied by a certified translation into Polish or English.
Insurance:
Each doctoral student, including a foreigner, admitted to the doctoral school is obligatorily subject to health insurance if he/she is not covered by such insurance on other grounds (e.g. employment relationship, contract of mandate, business activity, insured as a family member under 26 years of age, as the spouse of an insured person). The health insurance contribution is paid by Jagiellonian University and is financed from the State budget. In addition, a doctoral student receiving a doctoral scholarship is subject to compulsory retirement and disability insurance and accident insurance
IMPORTANT:
A person admitted to the doctoral school begin education and acquire doctoral student rights upon taking the oath. The Department of Personal Affairs reports each doctoral student admitted to the School to compulsory health and social insurance at the commencement of education, i.e. from 1 October at the earliest. Until that time foreign candidates are obliged to cover the costs of insurance for the time of travel, treatment, etc. individually.
Polecamy również
Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental therapy (Supervisor: Prof. dr hab. Stefan Chłopicki)
Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental therapy (Supervisor: Prof. dr hab. Stefan Chłopicki)