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Kontakt:
Maksymilian Szymczak
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High pressure studies of the structure of selected proteins in crystal and solution / Development of GI-SAXS stage for SOLCRYS beamline and studies of model lipid-metal nanoparticle systems using SAXS and XAS (Supervisors: prof. dr hab. Maciej Kozak/dr inż. Joanna Sławek)
Project description
1st Project description: The stability of the 3D structure of proteins under extreme conditions (high pressures, high temperatures, extreme pH or ionic strength values, etc.) is still one of the current problems in the fundamental research. The stability of the structure of protein complexes, oligomeric or monomeric proteins at high pressures is also of great importance in their industrial use. On the other hand, understanding the processes related to local structural disorder (e.g. changes in secondary structure) as well as long-range changes (dissociation of oligomeric structures or even complete unfolding of the tertiary structure) induced by pressure is important for understanding these phenomena in a broader (fundamental) context. It is particularly interesting to link these changes, induced by high pressure, with ranges of enzymatic activity or mechanisms of the misfolding of protein structures associated with neurodegenerative diseases (eg. human cystatin C or human prion protein). The aim of this project is to investigate the influence of high pressure (even up to 2 GPa) on the spatial structure of model proteins.
2nd Project description: Metallic nanoparticles are currently widely used in biology and medicine as components of drug delivery systems or bionanosensors, contrast systems in medical imaging or as enhancers in radiotherapy. In order to improve biocompatibility, nanoparticles are integrated in lipid systems (liposomes, multilamellar structures, etc.). However, the incorporation of nanoparticles induces structural changes in the lipid matrix. The aim of this project is to investigate the structure and organisation of lipid-metal nanoparticle systems, deposited on selected substrates, using GI-SAXS and analysis of interactions between metal core and lipid bilayers using combination of SAXS, XAS and complementary methods.
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