Przejdź do głównej treści

Widok zawartości stron Widok zawartości stron

Pomiń baner

Widok zawartości stron Widok zawartości stron

Widok zawartości stron Widok zawartości stron

Konwersatoria odbywają się o godz. 16:30 poprzez aplikację Webex (recording, privacy) i prowadzone są w języku angielskim.

Aby otrzymywać informacje o comiesięcznych konwersatoriach zarejestruj się pod linkiem.

Kontakt:
Maksymilian Szymczak

Widok zawartości stron Widok zawartości stron

Widok zawartości stron Widok zawartości stron

Breast cancer metastasis-induced endothelial-mesenchymal transition alongside ageing; implications for therapy (Supervisors: prof. S. Chłopicki/ dr Marta Smęda)

Breast cancer metastasis-induced endothelial-mesenchymal transition alongside ageing; implications for therapy (Supervisors: prof. S. Chłopicki/ dr Marta Smęda)

Description

Pursuant to § 7 sections 1 and 3 of Resolution No. 91/IX/2021 of the Senate of the Jagiellonian University of 29 September 2021 on the rules of recruitment for the Doctoral School of Exact and Natural Sciences at the Jagiellonian University in the academic year 2021/2022, the Director of the Doctoral School of Exact and Natural Sciences announces a competition for 1 doctoral student/s with a scholarship financed from the research project funds as part of the PhD study programme Biomedical Sciences.

Within the OPUS 21 funded project entitle Breast cancer metastasis-induced endothelial-mesenchymal transition alongside ageing; implications for therapy, a commission set up at the School will conduct recruitment for the PhD study programme Biomedical Sceinces in the academic year 2021/22.

The project manager dr Marta Smęda offers an opportunity to complete the doctorates in the following area: “Breast cancer metastasis-induced endothelial-mesenchymal transition alongside ageing; implications for therap”.

After the interviews and the evaluation of the candidates, the Chairman of the committee presents a report to the Director containing a list of candidates recommended for admission to the school as part of the research project.

Schedule of the competition

Detailed terms and procedures of admission.

Required documents

To make the application process fast and easy, please follow the rules.

Please send your application documents to the e-mail address of the Project Manager dr Marta Smęda. e-mail: marta.wojewoda@uj.edu.pl and through the Online Application System (OAS).

www.jcet.eu

Project description:

Endothelial dysfunction develops alongside ageing and is manifested by impaired NO-dependent relaxation of the vessels associated with compromised expression/activity of eNOS. Lower eNOS

levels in endothelial cells might be a hallmark of the already on-going mesenchymal transformation of endothelial cells (EndMT) which onset, progression, and consequences alongside ageing remain largely unknown although EndMT has been found to contribute to a plethora of diseases, including cancer.

Platelets, apart from their well-known role in thrombosis, protect endothelium both in health and alongside an inflammatory disease via the mechanisms recently termed as inflammation-associated haemostasis. The endothelium-protective function of platelets is especially important in the lungs whereby its loss compromises pulmonary endothelium barrier integrity, at least partly via the agents released from platelet granules after activation. However, platelet phenotype and the content of their granules may be changed alongside ageing and has been altered in cancer-bearing subjects what may result in the weakening/loss of platelet protective function.

The hypothesis of the project is that age- and cancer-altered platelets actively participate in age- and cancer-related EndMT that is associated with weaker endothelial barrier function. The aim of the project is to verify the abovementioned innovative hypothesis.

Documents required for enrollment

Polecamy również
Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental therapy (Supervisor: Prof. dr hab. Stefan Chłopicki)

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental therapy (Supervisor: Prof. dr hab. Stefan Chłopicki)

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental therapy (Supervisor: Prof. dr hab. Stefan Chłopicki)

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental therapy (Supervisor: Prof. dr hab. Stefan Chłopicki)

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental therapy (Supervisor: Prof. dr hab. Stefan Chłopicki)

Aging-associated, specific pathomechanisms of endothelial dysfunction in sepsis: pathway analysis and experimental therapy (Supervisor: Prof. dr hab. Stefan Chłopicki)

Identification and characterization of novel players in HIV-1 RNA nuclear processing and export to dissect post-transcriptional blocks in latency (Project Manager: dr Anna Kula-Pǎcurar)

Identification and characterization of novel players in HIV-1 RNA nuclear processing and export to dissect post-transcriptional blocks in latency (Project Manager: dr Anna Kula-Pǎcurar)