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29.02.2024 | High-throughput glycosylation analysis – challenges and perspectives – Irena Trbojević Akmačić, PhD

29 February 2024, 16:30

High-throughput glycosylation analysis - challenges and perspectives

Glycosylation is a co-translational and post-translational attachment of sugar moieties (glycans) to proteins. This complex process affects glycoprotein structure, proper folding, and its function. Glycans are essential for protein interactions on a cell surface, enable proper cell signalization and recognition, and are the result of both genetic and environmental factors. Aberrant glycosylation patterns have been associated with different diseases and have a high potential as diagnostic and prognostic disease biomarkers. To study glycosylation patterns of glycoproteins in large-scale human population, epidemiological and clinical studies, a lot of effort has been put into the development of robust, accurate, and fast methods for glycan analysis in hundreds and thousands of samples (so-called high-throughput methods). 

This lecture will cover a brief introduction on protein glycosylation, give an overview of currently used approaches for high-throughput glycosylation analysis with a focus on challenges, highlight several applications, and provide some future perspectives.

Irena Trbojević Akmačić, PhD

Dr. Irena Trbojević Akmačić is Head of Laboratory for high-throughput glycomics in Genos Ltd. She obtained Master’s degree in biochemistry and analytical chemistry and PhD degree in biochemistry with a focus on the analysis of IgG glycosylation in inflammatory bowel disease. Her research is focused on the development, optimization, and validation of plasma glycoproteins purification procedures, as well as technologies for subsequent N-glycan analysis, with application in high-throughput glycomic studies. She has mentored two PhD students and has co-authored over 60 scientific papers and book chapters.

Dates of the next seminars:

  • there will be no seminar in March
  • April 4th
  • April 25th
  • May 23rd
  • June 20th
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